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Future research might focus on real-time, high-resolution molecular imaging and multi-omics platforms that monitor copper dynamics in the brain and its binding states with critical proteins, on systematically screening and optimizing cellular and animal models to identify drug targets and small-molecule compounds that can balance removal of excess copper or replenishment of copper deficiency without disrupting the overall metal equilibrium, and on leveraging gene editing and immune modulation to reconstruct copper homeostasis and inflammatory pathways in the neural microenvironment for personalized therapies